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Jose Mourinho will be without the suspended Paul Pogba for the Manchester derby but Nemanja Matic has recovered from the knock that forced him to miss the 2-1 victory over CKSA Moscow, while Phil Jones and Zlatan Ibrahimovic are also fit to return.
Matic could perhaps be joined in central midfield by Ander Herrera, with Marouane Fellaini (knee) to be assessed over the next 24 to 48 hours.
The Man United boss could retain his recent 3-4-1-2 formation, with Jesse Lingard lining up in the No 10 role behind the front pairing of Romelu Lukaku and Anthony Martial.
Marcus Rashford and Juan Mata are the main attacking alternatives, though they both started in midweek whereas Lingard and Martial were omitted from the XI.
Antonio Valencia and Ashley Young are expected to start in the wing-back roles, while Jones could replace Victor Lindelof in the three-man backline, with Marcos Rojo and certainly Chris Smalling appearing more secure starters.
Eric Bailly (groin) and Michael Carrick (illness) won’t feature.