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Tiemoue Bakayoko, David Luiz and Ethan Ampadu have been ruled out for the trip to the Etihad, but Ross Barkley has trained this week, and is in the squad.
Up against the league leaders, Antonio Conte may consider switching from a 3-4-2-1 formation to a more defensive 3-5-1-1.
With Willian and Eden Hazard his two in-form attackers, it could be that they combine in attack with the Belgian operating in the lone striker role.
That would allow Cesc Fabregas to be recalled alongside Danny Drinkwater and N’Golo Kante in central midfield.
Given his lack of match fitness, Barkley will only be an option to come off the bench.
Alternatively, in a 3-4-2-1, Alvaro Morata may retain his start, with Olivier Giroud and Pedro the other options available to Conte.
Gary Cahill is the back-up option in central defence, while Davide Zappacosta provides cover for Victor Moses at right wing-back.