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Antonio Conte is set to make a raft of changes for the visit to Arsenal having rested players for the 5-0 win over Stoke City.
Eden Hazard and Cesc Fabregas look certain to return, while Tiémoué Bakayoko could also factor in midfield.
Andreas Christensen recovered from his recent illness to sit on the bench against the Potters and will surely be considered for a recall.
Those additions will likely see Danny Drinkwater, Willian and Pedro drop to the bench with Conte moving to a 3-5-1-1 system, deploying Hazard up in support of Alvaro Morata.
Antonio Rüdiger would seem most likely to give way in defence, while Davide Zappacosta could also earn a start ahead of Victor Moses at right wing-back.