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With Alvaro Morata available again following his one-match ban, Antonio Conte may revert back to the 3-5-1-1 formation for the home meeting with Brighton & Hove Albion.
That would allow Eden Hazard to return to a central support role, seeing Willian and Pedro drop to the bench.
Cesc Fabregas only played 27 minutes as a substitute in the goalless draw with Everton, so he looks poised to earn a recall in central midfield.
Danny Drinkwater could also be a viable starter after not featuring against the Toffees, with the pair perhaps joining N’Golo Kante in the middle of the park, potentially seeing Tiemoue Bakayoko make way.
Gary Cahill was also rested on the weekend so he looks poised to replace Antonio Rudiger in the three-man defence.
Davide Zappacosta replaced Victor Moses with nine minutes to go at Goodison Park, and the Italian could get the nod at right wing-back against the Seagulls.
David Luiz remains sidelined, while Charley Musonda (groin) is a doubt.