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Chris Smalling (groin) remains a major doubt for the home fixture against Southampton, while Matteo Darmian (knock) and Anthony Martial (knee) will be assessed after sitting out the 2-2 draw with Burnley.
Victor Lindelof was an unused substitute on Boxing Day and will be considered for a recall either at right-back or in central defence.
Antonio Valencia remains a major doubt due to a hamstring injury while Phil Jones and Marcos Rojo will likely be considered for a rest with a trip to Everton to follow two days later.
Paul Pogba and Nemanja Matic look poised to retain their starts at the base of midfield in the 4-2-3-1 formation, with Ander Herrera the main alternative.
Jesse Lingard starred as a substitute against Burnley and looks set to return as the No 10. He could be flanked by Juan Mata and Marcus Rashford, although if he’s available, Martial will challenge for a role on the flank.
Zlatan Ibrahimovic made his first league start of the season on Boxing Day but is expected to drop to the bench, leaving Romelu Lukaku as the lone striker.
Eric Bailly is a long-term absentee, while Marouane Fellaini (knee) and Michael Carrick (illness) remain sidelined.