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Olivier Giroud picked up a hamstring injury in the 1-0 win over West Ham United in the Carabao Cup and looks set to miss the home clash against Liverpool.
Alexandre Lacazette should spearhead the Gunners’ attack, with Alexis Sanchez and Alex Iwobi likely to flank the Frenchman.
Danny Welbeck scored the winner in midweek, though, and is a possible alternative to Iwobi.
Arsene Wenger has preferred a 4-1-2-3 formation of late, so Mesut Ozil and Jack Wilshere may again start in front of holding midfielder Granit Xhaka.
Francis Coquelin is a doubt with a knock picked he up against the Hammers, although Wenger stated the midfielder has a chance of being fit to face Liverpool.
Mohamed Elneny is the other more defensive option in the middle of the park. Shkodran Mustafi is available again following a thigh injury and could be return at the heart of the defence alongside Laurent Koscielny.
That could see Nacho Monreal replace Ainsley Maitland-Niles at left-back, with Sead Kolasinac looking unlikely to earn a recall.
Aaron Ramsey remains out, while Santi Cazorla is a long-term absentee.