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Antonio Conte admitted after the 1-0 win over Liverpool that he will rotate his side against Huddersfield Town.
So Andreas Christensen and potentially Davide Zappacosta and Emerson Palmieri could earn recalls at the back, leaving the starts of Victor Moses, Marcos Alonso and either Gary Cahill or Antonio Rudiger at risk.
The Blues boss is likely to consider using a more attacking 3-4-2-1 against the Terriers, so Willian could replace either Tiemoue Bakayoko or Cesc Fabregas, while Alvaro Morata is back in contention following a knock, and may replace Giroud up front.
David Luiz and Danny Drinkwater remain out.