This is their second Champions League defeat this season and it adds with six competitive lost matches at same stadium.
Harry Kane, Mousa Dembele, Toby Alderweireld, Erik Lamela and Danny Rose are ruled out with injury and it causes big impact on Mauricio Pochettino’s team.
But, Hugo Lloris is expecting a big miracle on their Champions League run and derby clash against Arsenal on Sunday.
He said: “We cannot be in a worse situation. It is difficult to accept that kind of performance from us. It was difficult to recognise the team, very aggressive, very calm under pressure, and that was completely the opposite.
“We need to learn quickly because there is a big game in Sunday. The derby is always important and we need to forget about this disappointment and be ready.”
He believes that injuries of few players will not affect the entire team’s performance.
“We cannot depend on one, two or three players. We need to think as a team.”
“In football there are ups and downs. It is difficult because this game was every important and I did not feel we were aware of that. Leverkusen did not play a great game. They were just well-organised and had some chances because of us, because we made too many mistakes.”