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Alvaro Morata and Pedro are suspended for the trip to Brighton & Hove Albion are both being sent off for two bookable offences in the FA Cup third round replay against Norwich City.
Meanwhile, Gary Cahill and Cesc Fabregas have both been ruled out due to hamstring injuries. Blues boss Antonio Conte also stated that a few other situations need to be checked, leaving the Italian desperately short of options.
Omitted from the midweek starting XI, Andreas Christensen should return to the three-man backline alongside Cesar Azpilicueta and Antonio Rudiger, then, though Azpilicueta did play 120 minutes on Wednesday night.
Victor Moses and Marcos Alonso were both rested and should start at right wing-back and left wing-back respectively.
Tiemoue Bakayoko was another to endure 120 minutes in the FA Cup tie, while Danny Drinkwater logged 100 minutes.
Ross Barkley is in the squad, although he’s unlikely to be fit enough to start, while David Luiz may be considered for a midfield role if needs must.
So even though he played the full match against Norwich, Willian may start alongside Eden Hazard in the attacking midfield positions, with Michy Batshuayi considered in the lone striker role.
Alternatively, Hazard may play as the lone striker, with Willian in a central support role in a 3-5-1-1 system.