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Aaron Ramsey has been ruled out for three weeks with a hamstring problem, and will miss the home clash against Newcastle United.
Arsene Wenger revealed Shkodran Mustafi has returned to training following a thigh injury, but added that it would be a little gamble to start the German.
Arsene Wenger switched to a 4-2-3-1 formation in midweek and may retain that system against the Magpies.
Sead Kolasinac was rested on Wednesday night, so he should replace Ainsley Maitland-Niles at left-back.
Nacho Montreal could again partner Laurent Koscielny in central defence if Mustafi isn’t risked.
Wenger hinted that Jack Wilshere may be left out after the midfielder played the full 90 minutes in the goalless draw with West Ham United.
So either Mohamed Elneny or Francis Coquelin could start alongside Granit Xhaka in central midfield.
Alexis Sanchez, Mesut Ozil and Alex Iwobi may again form the attacking midfield trio, with Alexandre Lacazette likely to replace Olivier Giroud as the lone striker.
Wenger revealed Lacazette has recently had a groin problem, and was rested on Wednesday night. Danny Welbeck is also a viable starter in the front four positions.
Alternatively, in a 3-4-2-1, Per Mertesacker or Mustafi, if fit, could start in defence, with Iwobi making way.
Santi Cazorla is a long-term absentee for the Gunners, while Theo Walcott (groin) remains out.