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After using a more defensive 4-3-3 formation in the Manchester derby, Jose Mourinho is expected to revert back to a 4-2-3-1 system for the home fixture against bottom side West Bromwich Albion.
Ander Herrera is likely to drop to the bench, then, with Paul Pogba joining Nemanja Matic installed in the double-pivot.
That would free up a spot for one of Juan Mata, Marcus Rashford or Anthony Martial to start in the attacking midfield positions.
The United boss has plenty of options to make changes in defence, with Marcos Rojo, Victor Lindelof and Phil Jones the possible alternatives should Mourinho look to rotate. Sergio Romero remains sidelined.