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Antonio Valencia (hamstring) missed the EFL Cup defeat to Bristol City and remains a big doubt for the trip to Leicester City.
If the Ecuadorian is ruled out, Matteo Darmian could deputise or Ashley Young could move over to right-back, with Marcos Rojo the likelier candidate on the left ahead of Luke Shaw and Daley Blind.
Phil Jones and Chris Smalling were rested in midweek and look set to form the centre-back partnership, with Rojo and Victor Lindelof the back-up options.
Paul Pogba got 90 minutes under his belt on Wednesday night following a three-match ban and should partner Nemanja Matic at the base of midfield in a 4-2-3-1 formation.
The Serbian, along with Juan Mata and Jesse Lingard, were rested in the cup, so all three appear likely starters against the Foxes.
Anthony Martial and Marcus Rashford both played the full match against Bristol City, though the former featured for just 11 minutes against West Brom on Sunday and could be handed the left wing role.
Romelu Lukaku only played 29 minutes in midweek, so he should lead the line, with Zlatan Ibrahimovic providing back-up.
Eric Bailly is a long-term absentee, while Marouane Fellaini (knee) and Michael Carrick (illness) are set to miss out once again.