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Alberto Moreno will miss the Merseyside derby after being forced off with an ankle injury in the 7-0 UEFA Champions League win over Spartak Moscow.
Jurgen Klopp said the Spaniard will undergo further assessment, with it not yet known whether he’ll be out for a week or a couple of weeks, perhaps even until the New Year.
In Moreno’s absence, James Milner could deputise at left-back ahead of Andrew Robertson.
With Joel Matip remaining a major doubt due to a muscle injury, Dejan Lovren looks set to partner Ragnar Klavan in central defence – the Croatian was taken off after 60 minutes on Wednesday night, presumably with one eye on Sunday.
As the first choice right-back in the absence of Nathaniel Clyne, Joe Gomez may get the nod over Trent Alexander-Arnold, despite playing 90 minutes in midweek. Klopp trialled a 4-1-4-1 in midweek but is expected to return to 4-3-3 formation.
Jordan Henderson should return in central midfield after being an unused substitute on Wednesday night, with Philippe Coutinho expected to take another of the midfield slots if Mohamed Salah, Roberto Firmino and Sadio Mane start in attack.
That would leave one of Georginio Wijnaldum, Emre Can or, potentially, Milner battling for the final spot in the three-man midfield. Daniel Sturridge and Dominic Solanke provide the back-up options in attack.
Adam Lallana continues to build up his fitness following a spell on the sidelines.