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Marcos Rojo, Ander Herrera and Jesse Lingard will miss out in Gameweek 8, though Ashley Young’s problem is “minor” and the veteran full-back could come back into the United squad this weekend.
Marcus Rashford impressed on the left flank against Valencia on Tuesday and he may benefit from Lingard’s absence on either wing.
Anthony Martial is also a strong candidate to displace Alexis Sanchez on the left, while Juan Mata is another alternative in those advanced midfield positions.
Antonio Valencia struggled in the Champions League in midweek and his place at right-back could come under threat from Young (if fit) or Diogo Dalot, while Nemanja Matic faces competition from Fred and Andreas Pereira in central midfield.
Mourinho’s experiment with Scott McTominay at centre-back looks unlikely to be repeated, though the United boss could give the 3-5-2 another try with Eric Bailly or Phil Jones brought in alongside Chris Smalling and Victor Lindelof.