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After being an unused substitute in the 3-0 win over Huddersfield Town, Virgil van Dijk is expected to return to the side for the home clash against Tottenham Hotspur.
The Dutch defender will likely replace Dejan Lovren in what may otherwise be an unchanged back four.
Georginio Wijnaldum and Alex Oxlade-Chamberlain only played seven minutes apiece as substitutes on Tuesday night, so they could push for recalls in place of James Milner and Jordan Henderson.
The front three should stay unchanged, with Dominic Solanke and Danny Ings providing cover. Ragnar Klavan and Adam Lallana both remain doubtful due to muscle injuries, while Nathaniel Clyne remains sidelined.