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Alexis Sanchez (hamstring) was ruled out for up to six weeks by his manager on Friday, having picked up an injury in training.
Sanchez joins Victor Lindelof (muscle) on the treatment table, with the Swede’s position at centre-back possibly set to be filled by Phil Jones – although Eric Bailly and, if fit, Marcos Rojo are alternatives alongside Chris Smalling.
Luke Shaw is back from suspension and will likely return at left-back, while Mourinho said Diogo Dalot will get his “first call” – while that could just mean bench duty, the fact that the United boss mentioned Ashley Young was on four yellow cards and that Mourinho may want the veteran England defender available for the visit of Arsenal next week perhaps suggests Dalot will make his first league start of the season.
Romelu Lukaku and Paul Pogba were dropped to the bench in midweek and could be back in contention for the trip to the south coast, with Juan Mata, Marcus Rashford and Jesse Lingard perhaps competing for the third attacking spot alongside Lukaku and Anthony Martial in a front three.
Fred, Scott McTominay and Ander Herrera are alternative options in the midfield three, though Mourinho was effusive in his praise of Marouane Fellaini on Friday and the Belgian could start again at St. Mary’s.