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Mauricio Pochettino has dropped Welsh international Ben Davies in favor of Danny Rose against Liverpool on Saturday.
Dele Alli and Hugo Lloris are out of contention due to injury with Michel Vorm and 22-year-old Harry Winks making their first Premier League start of the season.
Spurs revert to a back four with Toby Alderweireld and Jan Vertonghen at the heart of the defence – Davinson Sanchez misses out.
Son returns to the bench, alongside Sanchez, Erik Lamela, Victor Wanyama and Serge Aurier.
#THFC: Vorm, Trippier, Alderweireld, Vertonghen, Rose, Dier, Dembele, Winks, Eriksen, Lucas, Kane (C).
— Tottenham Hotspur (@SpursOfficial) September 15, 2018
Both Team starting LineUp
Tottenham: Vorm, Trippier, Alderweireld, Vertonghen, Rose, Dier, Dembele, Winks, Eriksen, Lucas, Kane (C).
Liverpool: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Milner, Wijnaldum, Keita, Mane, Salah, Firmino.