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Sergio Aguero (muscle) and Kevin De Bruyne (knee) will miss out on the trip to Chelsea on Saturday, though both are nearing a return according to their manager.
Gabriel Jesus will likely continue up front, then, with Raheem Sterling also a strong candidate to return on the flank after his rest at Watford.
Who joins those two players in attack is tough to predict, though Leroy Sane hasn’t started one match against a “big six” club this season – the disclaimer being that Benjamin Mendy was fit for all those games.
That Sane has started four matches in 11 days perhaps gives Riyad Mahrez the edge; the Algerian’s inclusion in the starting XI would mean that Sterling switches over to the left wing.
Ilkay Gundogan is an alternative option to Fernandinho, David Silva and Bernardo Silva in midfield, while Aymeric Laporte will surely return to the starting XI at the expense of Vincent Kompany after his first benching of the season.
Nicolas Otamendi, who also was named as a substitute on Tuesday, could potentially oust John Stones from the centre of defence, too.
No update was provided on Oleksandr Zinchenko (facial injury) in Guardiola’s press conference on Friday, but Mendy (knee) remains sidelined.