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Five Manchester United players picked up further injuries during the international break.
They were Diogo Dalot, Marouane Fellaini, Nemanja Matic, Scott McTominay and Luke Shaw, all of whom are a doubt for Gameweek 9.
Jose Mourinho suggested that Ander Herrera may be able to come back this week.
Alexis Sanchez could return to the starting line-up after scoring the winning goal against Newcastle last time out.
After an impressive second-half display in that match, Anthony Martial should hold onto his place.