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Ashley Young, Alexis Sanchez and Victor Lindelof are Manchester United three major absentees against Arsenal, with both facing lengthy lay-offs.
Sanchez tore his hamstring in his right leg during training on Thursday, which Jose Mourinho fears will keep the Chilean out for six weeks.
Lindelof, too, will miss much of December, following a groin injury sustained against Crystal Palace last week.
Young will be suspended for the visit of the Gunners after receiving a booking away at St Mary’s Stadium. He is joined on the list of unavailable players by the injured duo of Alexis Sanchez and Victor Lindelof.
Luke Shaw is available again after serving a suspension against Palace, while Diogo Dalot is set to start at right back.
The Gunners will take on United at Old Trafford on Wednesday evening, with the visitors hoping to take advantage of Mourinho’s dwindling options, especially at the back.
Victor Lindelof Groin injury (out)
Alexis Sanchez Hamstring injury (out)
Matteo Darmian Missed training (doubt)
Marcos Rojo Missed training (doubt)