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After handing opportunities to some fringe players against Brighton & Hove Albion, Jose Mourinho may revert to a more familiar starting XI against West Ham United.
Alexis Sanchez could be ready to return from a knock, but Romelu Lukaku (foot) is expected to remain sidelined.
So Sanchez is an option either on the left of a front three, or perhaps even as the central striker in Lukaku’s likely absence.
Jesse Lingard only featured as a substitute against the Seagulls, so he should also earn a recall.
That would leave Marcus Rashford, Juan Mata and Anthony Martial battling for one spot, with the former likely to be favoured.
Providing Mourinho sticks with a 4-3-3, Ander Herrera is expected to return in central midfield, getting the nod ahead of Scott McTominay and Marouane Fellaini.
At the back, Phil Jones remains a doubt, so either Victor Lindelof or Eric Bailly may replace Marcos Rojo alongside Chris Smalling at the heart of the defence.
Antonio Valencia is expected to replace Matteo Darmian at right-back, with Ashley Young set to continue at left-back. Luke Shaw provides further cover at left-back.
Sergio Romero remains sidelined.